Bleomycin induced pneumonitis: a case successfully managed with high-dose steroids.
نویسندگان
چکیده
Bleomycin is a chemotherapeutic agent used in a number of solid organ malignancies.1-3 It accumulates in the skin and lungs resulting in skin ulceration and associated pulmonary toxicity. Its use is somewhat limited due to its significant pulmonary adverse effects with bleomycin induced pnemonitis (BIP) as the commonest and most dreaded complications. The overall incidence of pulmonary toxicity is as high as 10% and it is fatal in 1-2%.3,4
منابع مشابه
No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis
Bleomycin-induced pneumonitis (BIP) is a serious and potentially fatal adverse effect of bleomycin. Currently, BIP is treated on an empirical basis with high dose steroid. Pirfenidone is a new antifibrotic drug, which has been proven beneficial in idiopathic pulmonary fibrosis and is able to inhibit or reverse BIP in animal models. Here, the first two cases of human BIP treated with pirfenidone...
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air spaces and absence of hyperplastic pneumocytes (type II) with bizarre shapes usually noted in cases of bleomycin-induced interstitial pneumonitis.10 The pathologic changes described in our patient are different from those described for bleomycin hypersensitivity pneumonitis and appear to be a classic bleomycin intestitial pneumonitis.11 This case illustrates that life threatening bleomycin ...
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ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 57 2 شماره
صفحات -
تاریخ انتشار 2007